NFL 2021 Week 4 Divisional Games: NFC West Matchups

  • All teams in the NFC West will have games against a divisional opponent in Week 4.
  • The Seattle Seahawks are +130 on the moneyline against the San Francisco 49ers -150.
  • The Los Angeles Rams are 4.5-point betting favorites over the Arizona Cardinals.

SAN FRANCISCO – The NFC West standings will see some major changes after Week 4 of the NFL season as every team in the division is paired against one another for the week.

San Francisco 49ers Vs. Seattle Seahawks

The San Francisco 49ers and Seattle Seahawks will play one another on Sunday. Online gambling sites are labeling the 49ers as slight favorites in the matchup but could be on upset alert.

Seahawks Vs. 49ers Moneyline Odds

  • Seattle Seahawks +130
  • San Francisco 49ers -150

These two teams are currently at the bottom of the NFC West standings and the loser will be punished with sole possession of last place. Russell Wilson has a 15-4 record against San Francisco, which is the quarterback’s best record against any divisional foe. The +130 moneyline could be interesting to many but others may want to play it safer and go with the spread.

Seahawks vs 49ers Spread Odds

  • San Francisco 49ers -3.0 -115
  • Seattle Seahawks +3.0 -105

All four of Wilson’s losses to the 49ers have been by seven points or less and it’s tough to see that changing against a beat-up 49ers team.

The game will begin at 4:05 p.m. EST and will be broadcast on FOX.

Los Angeles Rams Vs. Arizona Cardinals

The Los Angeles Rams and Arizona Cardinals currently lead the division with undefeated records. However, one team will leave the weekend with a loss as the two faceoff against each other in Week 4. NFL betting sites expect it to be the Cardinals.

Rams Vs. Cardinals Spread Odds

  • Los Angeles Rams -4.5 -110
  • Arizona Cardinals +4.5 -110

The game has the highest total of the week at 55.0 points which translates to a projected shootout, which may favor the Rams. Last week, Los Angeles beat the Tampa Bay Buccaneers in a high-scoring affair, so this should be nothing new to them.

Both Kyler Murray and Matthew Stafford are towards the top of the NFL passing leaders board, but if the game ultimately comes down to whatever team can get the most stops, the Rams defense, anchored by Aaron Donald and Jalen Ramsey, likely have the advantage over the Cardinals.

At the end of the day, Murray has never beaten the Rams in his career and online sportsbooks don’t expect that to change on Sunday.

The kick-off is scheduled for 4:05 p.m. EST and can be seen on FOX.