NFL 2021 Week 5 Divisional Games: NFC West Matchups And Wagers

  • All teams in the NFC West will have games against divisional opponents in Week 5.
  • The Los Angeles Rams have EVEN odds to cover a 3-point spread against the Seattle Seahawks.
  • The Arizona Cardinals are 5.5-point betting favorites over the San Francisco 49ers.

SEATTLE - The entire NFC West will be in action against one another for the second week in a row.

Los Angeles Rams Vs. Seattle Seahawks

The Seattle Seahawks will be home underdogs for the first time since 2019 against the Los Angeles Rams. Online gambling sites are labeling QB Russell Wilson as an underdog at home for just the 10th time in his career.

Seahawks Vs. Rams Spread Odds

  • Los Angeles Rams -3.0 EVEN
  • Seattle Seahawks +3.0 -120

Wilson has covered the spread in six of his nine games as a home underdog thus far in his career and has won straight up five times. If this trend continues, the Seahawks could be a good moneyline bet, especially at +120 odds.

FOX and the NFL Network will have coverage of the Thursday Night Football game beginning at 8:20 p.m. EST.

San Francisco 49ers Vs. Arizona Cardinals

NFL betting sites are giving the Arizona Cardinals a good chance to extend their undefeated streak past the San Francisco 49ers on Sunday. This could be due to the Jimmy Garoppolo injury that may force him to miss the game.

49ers Vs. Cardinals Spread Odds

  • San Francisco 49ers +5.5 -110
  • Arizona Cardinals -5.5 -110

Arizona has the highest-powered offense in the NFL as they average both the most yards and most points per game. A rookie quarterback, Trey Lance, is unlikely to be able to match the output, which could spell trouble for San Francisco in this game.

The game is scheduled for a 4:25 p.m. EST start on Sunday and can be viewed on FOX.

NFC West Division Odds

The division odds are subject to change after the week, as teams will establish a lead over their divisional rivals. As it stands, the Cardinals are slight favorites with the Rams close behind.

NFC West Division Odds

  • Arizona Cardinals +150
  • Los Angeles Rams +175
  • Seattle Seahawks +400
  • San Francisco 49ers +600

If there were to be an upset or two this week, these odds could look much closer to one another on Monday morning, however, if the favorites hold true, the gap will likely widen between the top and bottom teams.